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human dna methylation beadchip arrays 27k  (Illumina Inc)


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    Illumina Inc human dna methylation beadchip arrays 27k
    The molecular aging process in cells affects the genome integrity and the <t>DNAm</t> signature. The ends of chromosomes are organized as telomeric complexes. Telomeres comprise of [TTAGGG] n tandem repeats of double-stranded <t>DNA</t> and protruding single-stranded 3’-overhangs. Due to the absence of telomerase activity in healthy somatic cells gradual telomere shortening with each cell cycle is an age-dependent process, which limits the maximum number of cell divisions, thus providing a protective anti-proliferative mechanism. Telomere length is correlated with biological aging. However, their length of origin at the beginning of ontogeny seems to be heterogeneous between sexes and ethnicities , which complicates calibration when longitudinal measurements are not available. Whereas genome-wide studies on DNAm signatures in monozygotic twins suggest a high level of persistence of early genome programming , subtle changes in numerous genetic loci are observed at the same time, which correlate with biological age. These form the basis for the concept of so-called epigenetic clocks [ – ]. Such age-related DNAm variations can take place in intergenic regions (yellow shaded) as well as in the vicinty of gene promoters (red shaded), where they can take influence on gene regulation. The frequently used ‘Horvath clock’ is, in combination with Illumina’s Infinium HumanMethylome450 BeadChips, calibrated for 353 CpG sites, which can be associated with genes, promoters, long-range regulatory elements or intergenic DNA with no known function [ , ]. The illustration exemplarily shows an age-related hypermethylated intergenic region as well as a hypomethylated gene promoter during fetal growth that cis-activates mRNA synthesis from adjacent transcription start site (TSS). Below are shown the results of senescence, whereafter the same intergenic region became hypomethlylated and the promoter became hypermethylated. Promoter hypermethylation resulted in the suppression of mRNA synthesis from the adjacent TSS
    Human Dna Methylation Beadchip Arrays 27k, supplied by Illumina Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+beadchip+27k+array/illumina+arrays/pmc11534990-185-14-13
    Average 90 stars, based on 1 article reviews
    human dna methylation beadchip arrays 27k - by Bioz Stars, 2026-09
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    1) Product Images from "A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders – a systematic review"

    Article Title: A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders – a systematic review

    Journal: Neurogenetics

    doi: 10.1007/s10048-024-00771-x

    The molecular aging process in cells affects the genome integrity and the DNAm signature. The ends of chromosomes are organized as telomeric complexes. Telomeres comprise of [TTAGGG] n tandem repeats of double-stranded DNA and protruding single-stranded 3’-overhangs. Due to the absence of telomerase activity in healthy somatic cells gradual telomere shortening with each cell cycle is an age-dependent process, which limits the maximum number of cell divisions, thus providing a protective anti-proliferative mechanism. Telomere length is correlated with biological aging. However, their length of origin at the beginning of ontogeny seems to be heterogeneous between sexes and ethnicities , which complicates calibration when longitudinal measurements are not available. Whereas genome-wide studies on DNAm signatures in monozygotic twins suggest a high level of persistence of early genome programming , subtle changes in numerous genetic loci are observed at the same time, which correlate with biological age. These form the basis for the concept of so-called epigenetic clocks [ – ]. Such age-related DNAm variations can take place in intergenic regions (yellow shaded) as well as in the vicinty of gene promoters (red shaded), where they can take influence on gene regulation. The frequently used ‘Horvath clock’ is, in combination with Illumina’s Infinium HumanMethylome450 BeadChips, calibrated for 353 CpG sites, which can be associated with genes, promoters, long-range regulatory elements or intergenic DNA with no known function [ , ]. The illustration exemplarily shows an age-related hypermethylated intergenic region as well as a hypomethylated gene promoter during fetal growth that cis-activates mRNA synthesis from adjacent transcription start site (TSS). Below are shown the results of senescence, whereafter the same intergenic region became hypomethlylated and the promoter became hypermethylated. Promoter hypermethylation resulted in the suppression of mRNA synthesis from the adjacent TSS
    Figure Legend Snippet: The molecular aging process in cells affects the genome integrity and the DNAm signature. The ends of chromosomes are organized as telomeric complexes. Telomeres comprise of [TTAGGG] n tandem repeats of double-stranded DNA and protruding single-stranded 3’-overhangs. Due to the absence of telomerase activity in healthy somatic cells gradual telomere shortening with each cell cycle is an age-dependent process, which limits the maximum number of cell divisions, thus providing a protective anti-proliferative mechanism. Telomere length is correlated with biological aging. However, their length of origin at the beginning of ontogeny seems to be heterogeneous between sexes and ethnicities , which complicates calibration when longitudinal measurements are not available. Whereas genome-wide studies on DNAm signatures in monozygotic twins suggest a high level of persistence of early genome programming , subtle changes in numerous genetic loci are observed at the same time, which correlate with biological age. These form the basis for the concept of so-called epigenetic clocks [ – ]. Such age-related DNAm variations can take place in intergenic regions (yellow shaded) as well as in the vicinty of gene promoters (red shaded), where they can take influence on gene regulation. The frequently used ‘Horvath clock’ is, in combination with Illumina’s Infinium HumanMethylome450 BeadChips, calibrated for 353 CpG sites, which can be associated with genes, promoters, long-range regulatory elements or intergenic DNA with no known function [ , ]. The illustration exemplarily shows an age-related hypermethylated intergenic region as well as a hypomethylated gene promoter during fetal growth that cis-activates mRNA synthesis from adjacent transcription start site (TSS). Below are shown the results of senescence, whereafter the same intergenic region became hypomethlylated and the promoter became hypermethylated. Promoter hypermethylation resulted in the suppression of mRNA synthesis from the adjacent TSS

    Techniques Used: Activity Assay, Genome Wide

    Summary of epigenetic age studies in various brain regions and mental disorders
    Figure Legend Snippet: Summary of epigenetic age studies in various brain regions and mental disorders

    Techniques Used: Control, Expressing, DNA Methylation Assay, Gene Expression

    Related Articles

    Biomarker Discovery:

    Article Title: A CpG Methylation Signature as a Potential Marker for Early Diagnosis of Hepatocellular Carcinoma From HBV-Related Liver Disease Using Multiplex Bisulfite Sequencing
    Article Snippet: .. Based on the Illumina Human Beadchip 27K array, sphingomyelin phosphodiesterase 3 (SMPD3) and neurofilament, heavy polypeptide (NEFH) were found to behave as tumor suppressor genes in HCC after validation in vitro and in vivo ( ). ..

    Article Title: A CpGs Methylation Signature as Potential Marker for Early Diagnosis of Hepatocellular Carcinoma from HBV-Related Liver Disease using Multiplex Bisulfite Sequencing
    Article Snippet: .. Basing on Illumina Human Beadchip 27K array, sphingomyelin phosphodiesterase 3 (SMPD3) and neuro lament, heavy polypeptide (NEFH) were found to behave as tumor suppressor genes in HCC after validation in vitro and in vivo [34]. ..

    In Vitro:

    Article Title: A CpG Methylation Signature as a Potential Marker for Early Diagnosis of Hepatocellular Carcinoma From HBV-Related Liver Disease Using Multiplex Bisulfite Sequencing
    Article Snippet: .. Based on the Illumina Human Beadchip 27K array, sphingomyelin phosphodiesterase 3 (SMPD3) and neurofilament, heavy polypeptide (NEFH) were found to behave as tumor suppressor genes in HCC after validation in vitro and in vivo ( ). ..

    Article Title: A CpGs Methylation Signature as Potential Marker for Early Diagnosis of Hepatocellular Carcinoma from HBV-Related Liver Disease using Multiplex Bisulfite Sequencing
    Article Snippet: .. Basing on Illumina Human Beadchip 27K array, sphingomyelin phosphodiesterase 3 (SMPD3) and neuro lament, heavy polypeptide (NEFH) were found to behave as tumor suppressor genes in HCC after validation in vitro and in vivo [34]. ..

    In Vivo:

    Article Title: A CpG Methylation Signature as a Potential Marker for Early Diagnosis of Hepatocellular Carcinoma From HBV-Related Liver Disease Using Multiplex Bisulfite Sequencing
    Article Snippet: .. Based on the Illumina Human Beadchip 27K array, sphingomyelin phosphodiesterase 3 (SMPD3) and neurofilament, heavy polypeptide (NEFH) were found to behave as tumor suppressor genes in HCC after validation in vitro and in vivo ( ). ..

    Article Title: A CpGs Methylation Signature as Potential Marker for Early Diagnosis of Hepatocellular Carcinoma from HBV-Related Liver Disease using Multiplex Bisulfite Sequencing
    Article Snippet: .. Basing on Illumina Human Beadchip 27K array, sphingomyelin phosphodiesterase 3 (SMPD3) and neuro lament, heavy polypeptide (NEFH) were found to behave as tumor suppressor genes in HCC after validation in vitro and in vivo [34]. ..

    Genome Wide:

    Article Title: Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma
    Article Snippet: .. METHODS We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina Human Beadchip 27K array; data were combined with those from microarray analysis of gene re-expression in 4 liver cancer cell lines after their exposure to reagents that reverse DNA methylation (epigenetic unmasking). ..

    Article Title: Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma
    Article Snippet: .. We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina Human Beadchip 27K array; data were combined with those from microarray analysis of gene re-expression in 4 liver cancer cell lines after their exposure to reagents that reverse DNA methylation (epigenetic unmasking). ..

    Methylation:

    Article Title: Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma
    Article Snippet: .. METHODS We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina Human Beadchip 27K array; data were combined with those from microarray analysis of gene re-expression in 4 liver cancer cell lines after their exposure to reagents that reverse DNA methylation (epigenetic unmasking). ..

    Article Title: Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma
    Article Snippet: .. We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina Human Beadchip 27K array; data were combined with those from microarray analysis of gene re-expression in 4 liver cancer cell lines after their exposure to reagents that reverse DNA methylation (epigenetic unmasking). ..

    Microarray:

    Article Title: Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma
    Article Snippet: .. METHODS We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina Human Beadchip 27K array; data were combined with those from microarray analysis of gene re-expression in 4 liver cancer cell lines after their exposure to reagents that reverse DNA methylation (epigenetic unmasking). ..

    Article Title: Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma
    Article Snippet: .. We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina Human Beadchip 27K array; data were combined with those from microarray analysis of gene re-expression in 4 liver cancer cell lines after their exposure to reagents that reverse DNA methylation (epigenetic unmasking). ..

    DNA Methylation Assay:

    Article Title: Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma
    Article Snippet: .. METHODS We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina Human Beadchip 27K array; data were combined with those from microarray analysis of gene re-expression in 4 liver cancer cell lines after their exposure to reagents that reverse DNA methylation (epigenetic unmasking). ..

    Article Title: Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma
    Article Snippet: .. We performed genome-wide methylation analysis of 71 human HCC samples using the Illumina Human Beadchip 27K array; data were combined with those from microarray analysis of gene re-expression in 4 liver cancer cell lines after their exposure to reagents that reverse DNA methylation (epigenetic unmasking). ..



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    Image Search Results


    The molecular aging process in cells affects the genome integrity and the DNAm signature. The ends of chromosomes are organized as telomeric complexes. Telomeres comprise of [TTAGGG] n tandem repeats of double-stranded DNA and protruding single-stranded 3’-overhangs. Due to the absence of telomerase activity in healthy somatic cells gradual telomere shortening with each cell cycle is an age-dependent process, which limits the maximum number of cell divisions, thus providing a protective anti-proliferative mechanism. Telomere length is correlated with biological aging. However, their length of origin at the beginning of ontogeny seems to be heterogeneous between sexes and ethnicities , which complicates calibration when longitudinal measurements are not available. Whereas genome-wide studies on DNAm signatures in monozygotic twins suggest a high level of persistence of early genome programming , subtle changes in numerous genetic loci are observed at the same time, which correlate with biological age. These form the basis for the concept of so-called epigenetic clocks [ – ]. Such age-related DNAm variations can take place in intergenic regions (yellow shaded) as well as in the vicinty of gene promoters (red shaded), where they can take influence on gene regulation. The frequently used ‘Horvath clock’ is, in combination with Illumina’s Infinium HumanMethylome450 BeadChips, calibrated for 353 CpG sites, which can be associated with genes, promoters, long-range regulatory elements or intergenic DNA with no known function [ , ]. The illustration exemplarily shows an age-related hypermethylated intergenic region as well as a hypomethylated gene promoter during fetal growth that cis-activates mRNA synthesis from adjacent transcription start site (TSS). Below are shown the results of senescence, whereafter the same intergenic region became hypomethlylated and the promoter became hypermethylated. Promoter hypermethylation resulted in the suppression of mRNA synthesis from the adjacent TSS

    Journal: Neurogenetics

    Article Title: A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders – a systematic review

    doi: 10.1007/s10048-024-00771-x

    Figure Lengend Snippet: The molecular aging process in cells affects the genome integrity and the DNAm signature. The ends of chromosomes are organized as telomeric complexes. Telomeres comprise of [TTAGGG] n tandem repeats of double-stranded DNA and protruding single-stranded 3’-overhangs. Due to the absence of telomerase activity in healthy somatic cells gradual telomere shortening with each cell cycle is an age-dependent process, which limits the maximum number of cell divisions, thus providing a protective anti-proliferative mechanism. Telomere length is correlated with biological aging. However, their length of origin at the beginning of ontogeny seems to be heterogeneous between sexes and ethnicities , which complicates calibration when longitudinal measurements are not available. Whereas genome-wide studies on DNAm signatures in monozygotic twins suggest a high level of persistence of early genome programming , subtle changes in numerous genetic loci are observed at the same time, which correlate with biological age. These form the basis for the concept of so-called epigenetic clocks [ – ]. Such age-related DNAm variations can take place in intergenic regions (yellow shaded) as well as in the vicinty of gene promoters (red shaded), where they can take influence on gene regulation. The frequently used ‘Horvath clock’ is, in combination with Illumina’s Infinium HumanMethylome450 BeadChips, calibrated for 353 CpG sites, which can be associated with genes, promoters, long-range regulatory elements or intergenic DNA with no known function [ , ]. The illustration exemplarily shows an age-related hypermethylated intergenic region as well as a hypomethylated gene promoter during fetal growth that cis-activates mRNA synthesis from adjacent transcription start site (TSS). Below are shown the results of senescence, whereafter the same intergenic region became hypomethlylated and the promoter became hypermethylated. Promoter hypermethylation resulted in the suppression of mRNA synthesis from the adjacent TSS

    Article Snippet: Eleven of the studies used Horvath’s model in combination with different versions of Illumina’s Human DNA Methylation BeadChip Arrays (27K, 450K, EPIC) to determine epigenetic ages [ , ].

    Techniques: Activity Assay, Genome Wide

    Summary of epigenetic age studies in various brain regions and mental disorders

    Journal: Neurogenetics

    Article Title: A perspective on epigenomic aging processes in the human brain and their plasticity in patients with mental disorders – a systematic review

    doi: 10.1007/s10048-024-00771-x

    Figure Lengend Snippet: Summary of epigenetic age studies in various brain regions and mental disorders

    Article Snippet: Eleven of the studies used Horvath’s model in combination with different versions of Illumina’s Human DNA Methylation BeadChip Arrays (27K, 450K, EPIC) to determine epigenetic ages [ , ].

    Techniques: Control, Expressing, DNA Methylation Assay, Gene Expression